IRG2: Engineered Non-Toxic Quantum Dots Systems for Cancer Therapy Applications PDF Print E-mail
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Wednesday, 07 July 2004 09:54

Oscar Perales (Co-PI), Luis Rivera, Maharaj S. Tomar and Surinder P. Singh

Medical science is the area where active nanotechnologies are having an incomparable impact. On a therapy basis, the emerging cancer treatment based on the photodynamic therapy (PDT) approach could fully modify the way how semiconductor Quantum Dots (QDs) would be used by promoting the singlet oxygen yield, responsible for killing of cancer cells, by using QDs alone or combined with conventional photo-sensitizers (PS), opens new possibilities for transformative research in cancer therapy.

Paradoxically, the most promising QDs structure is based on CdSe QDs, which are also considered the most cytotoxic ones. IRG2 proposed research will focus on the development and optimization of Cd-free QDs-based systems (ZnO/ZnS, ZnSe, ZnTe) to be used in PDT. PDT using semiconductor QDs dots as carriers is expected to show much higher efficiency and effectiveness in selective destruction of cancer cells. Novel QDs-based structures will be produced, characterized and tested in-vitro as biomarkers and as PDT agents for carcinogenic cells. Cytotoxicological tests will be performed to quantify the compatibility of produced QDs structures with selected biological systems. The broader impact of the IRG relates to the applicability of inorganic nanostructures in bio/medical research as new transformative research possibilities integrating the inorganic and organic worlds. The possibility of using QDs for localized and less traumatic PDT protocols will change the way how cancer is going to be faced in the future. In addition, novel options for such materials in cells labeling, chemical libraries, molecular recognition or biological assembling of inorganic nanostructures, are also envisioned. This IRG aims at impacting on the 3rd and 4th generations, as defined by Roco. The IRG2 team (as evinced by the biographical sketches) encompasses highly productive and experienced researchers (Perales, Tomar, Rivera) with a newly hired ESM faculty with outstanding research background.

Last Updated on Sunday, 16 November 2008 18:19
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