Research Group 1
Scientific Breakthrough PDF Print E-mail
Thursday, 15 September 2011 00:00

CREST Researchers Demonstrate Capacity of Targeted Magnetic Nanoparticles to Destroy Cancer Cells Through Heat Delivered at the Nanoscale

CREST IRG1 researchers have recently demonstrated that magnetic nanoparticles conjugated to the protein epidermal growth factor receptor target breast cancer cells that over-express the epidermal growth factor receptor (EGFR) and can lead to significant (>99%) reductions in cell survival upon the application of an alternating magnetic field. An important feature of this demonstration is that significant reductions in cell viability are achieved using only internalized nanoparticles and without a macroscopic perceptible temperature rise. The study was conducted by visiting student Mar Creixell Turon, of the University of Barcelona, who conducted her doctoral dissertation research under the supervision of Prof. Carlos Rinaldi. Graduate student Ana C. Bohórquez and Prof. Madeline Torres-Lugo also contributed to the study.

Last Updated on Sunday, 25 September 2011 13:39
IRG1: Multifunctional Nanoparticles for Magnetically Actuated siRNA Delivery PDF Print E-mail
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Wednesday, 07 July 2004 09:54

Carlos Rinaldi (Co-PI), Madeline Torres and Eduardo Juan

This Interdisciplinary Research Group (IRG) proposes to develop heterogeneous multifunctional nanoparticles with a magnetic core and a thermoresponsive block copolymer coating, suitable for the magnetically actuated delivery of siRNA to cells. Monodisperse magnetic nanoparticles will be prepared by thermal decomposition of organometallic precursors and coated with A-B block copolymers.

Last Updated on Monday, 11 January 2010 17:51

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NCBEDSA is a National Science Foundation (NSF) Center for Research Excellence in Science and Technology (CREST) at the University of Puerto Rico at Mayagüez
University of Puerto Rico-Mayagüez